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. 2023 Feb 6;24(4):3196. doi: 10.3390/ijms24043196

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Construction of communication network between npEXO ligands and non-CMs in the adult heart. (A) Venn diagram showing GO results (BP enrichment) of npEXO ligands against those of non-CM receptors in the adult heart. (B) Heatmap of the npEXO ligands involved in npEXO and adult non-CM communication network. Clusters are assembled by GO analysis. The significantly enriched items and representative genes are shown on the left. (C) Heatmap displaying the expression of receptor genes involved in npEXO and non-CM communication network of the adult heart. (D) Sum of all communication network receptor genes expressed in each non-CM population. (E) Correlation analysis showed receptors expressed in endothelial cells (ECs) and pathways participated in a communication network.