3p-hpRNA	5′ Triphosphate hairpin RNA
ABC	Accelerated blood clearance
AD	Adenosine deaminase
ADA	Antidrug antibodies
ADC	Antibody–drug conjugate
ADCC	Antibody-dependent cell-mediated cytotoxicity
ADCP	Antibody-dependent cell-mediated phagocytosis
AOC	Antibody–oligonucleotide conjugate
APA	Anti-PEG antibodies
ASO	Antisense oligonucleotide
ATRP	Atom-transfer radical polymerization
AUC	Area under the curve
BBB	Blood–brain barrier
BCMA	B-cell maturation antigen
bis-MPA	Poly-2,2-bis(hydroxymethyl)propionic acid
BLA	Biologics license application
B-peptide	Arginine-rich cell-penetrating peptide
BSA	Bovine serum albumin
CDC	Complement dependent cytotoxicity
CMC	Chemistry, manufacturing, and controls
CMV	Cytomegalovirus
CNS	Central nervous system
CpG	Cytosine–phosphate–guanine dinucleotide
CPP	Cell-penetrating peptide
CRM197	Attenuated form of C. diphtheriae toxin
DAR	Drug to antibody ratio
DBCO	Dibenzocyclooctyne
DP	Drug product
DM1*	Myotonic dystrophy type 1
DS	Drug substance
DT	Diphtheria toxoid
DVD	Dual variable domain antibody
dsASO	Double-stranded ASO
EGFR	Epidermal growth factor receptor
ELP	Elastin-like polypeptides
Fab	Antibody fragment
Fc	Antibody constant fragment
FcRn	Neonatal Fc receptor
FDA	Food and Drug Administration
FSHD	Facioscapulohumeral muscular dystrophy
GA	Geographic atrophy
GAC	Streptococcus pyrogen group A carbohydrate
GalNac	N-Acetylgalactosamine
G-CSF	Human granulocyte colony-stimulating factor
GFP	Green Fluorescent Protein
GMAB	Modified lupus autoantibody
HA	Hyaluronic acid
hGH	Human growth hormone
HiB	Haemophilus influenzae serotype b
HIV-1	Human immunodeficiency virus type I
HPMA	(2-hydroxylpropyl)methacrylamide
HTS	High-throughput screening
IM	Intramuscular
IND	Investigational new drug
IP	Intraperitoneal
IT	Intrathecal
ITV	Intravitreal
IV	Intravenous
LMWP	Low molecular weight protamine
LNP	Lipid nanoparticle
mAb	Monoclonal antibody
MG	Myasthenia gravis
miR	MicroRNA
MMAE	Monomethyl auristatin E
MMAF	Monomethyl auristatin F
MMC	Multiple myeloma cells
MSP	Muscle targeting heptapeptide
nAMD	Neovascular age-related macular degeneration
N/A	Not available
NDA	New drug application
NHS	N-hydroxysuccinimide
nnAA	Non-native amino acid
NTHi	Haemophilus influenzae
OPS	O antigen polysaccharides
OMPC	Outer membrane protein complex of serogroup B meningococcus
PABC	Para-amino benzyloxycarbonyl
PAD	Peripheral artery disease
pAMF	P-azidomethyl phenylalanine
PAMAM	Poly(amidoamine)
PAS	Proline/alanine-rich sequences
PBD	Pyrrolobenzodiazepine
pCB	Poly(carboxybetaine)
PCV	Pneumococcal conjugate vaccine
PD	Haemophilus influenzae protein D
PEG	Polyethylene glycol
PK	Pharmacokinetics
PMO	Phosphorodiamidate morpholino oligonucleotide
PNA	Peptide nucleic acid
PNAG	Poly-N-acetylglucosamine
POEGMA	Poly(oligo(ethylene glycol) methyl ether methacrylate
POZ	Poly(2-oxazoline)
PPC	Polysaccharide-based vaccine
pPC	Poly(phosphorylcholine)
PROTAC	Proteolysis targeting chimera
PRP	Polyribosyl ribitol phosphate
PSA	Polysialic acid
pSar	Polysarcosine
pSB	Poly(sulfobetaine)
PTH	Parathyroid hormone
pTMAO	Poly(trimethylamine N-oxide
RAFT	Reversible addition-fragmentation chain transfer polymerization
rEPA	Pseudomonas aeruginosa protein exotoxin A
RNAi	RNA inhibition
RVO	Retinal vein occlusion
SC	Subcutaneous
ScFv	Single-chain variable fragment
sDC	Synthetic dendritic cell
siRNA	Small interfering RNA
SLO	Streptolysin O
SMA	Spinal muscular atrophy
SSO	Splice-switching oligonucleotide
TAT	Transactivator of transcription from HIV-1
TDB	T-cell-dependent bispecific antibody
TFF	Tangential flow filtration
TfR1	Transferrin receptor
TI	Therapeutic index
TLR	Toll-like receptor
Tm	Melting temperature
TNF	Tumor necrosis factor
TT	Tetanus toxoid
Un-dPP	undecaprenyl pyrophosphate
Val-Cit	Valine-citrulline
VEGF	Vascular endothelial growth factor
VLP	Virus-like particle/nanoparticle
WHO	World Health Organization