Table 2.
Metabolic pathways associated with ligament, meniscal, and ligament and meniscal injuries identified by median metabolite intensity heatmap analysis. All reported pathways have a FDR-corrected significance level < 0.05. L = ligament injuries. M = meniscal injuries. LM = ligament and meniscal injuries. Clusters defined in Figure 2C.
| Cluster | Pathway | Highest | Lowest |
|---|---|---|---|
| 2 | Leukotriene metabolism | L | LM |
| 2 | Omega-6 fatty acid metabolism | L | LM |
| 2 | Vitamin E metabolism | L | LM |
| 2 | Arginine and Proline Metabolism | L | LM |
| 2 | Mono-unsaturated fatty acid beta-oxidation | L | LM |
| 2 | C5-Branched dibasic acid metabolism | L | LM |
| 2 | Ubiquinone Biosynthesis | L | LM |
| 2 | Vitamin B3 (nicotinate and nicotinamide) metabolism | L | LM |
| 3 | Aspartate and asparagine metabolism | L | LM |
| 3 | Glycine, serine, alanine and threonine metabolism | L | LM |
| 3 | Tryptophan metabolism | L | LM |
| 3 | Alanine and Aspartate Metabolism | L | LM |
| 3 | Butanoate metabolism | L | LM |
| 3 | Carnitine shuttle | L | LM |
| 3 | Lysine metabolism | L | LM |
| 3 | Pyrimidine metabolism | L | LM |
| 2 | C21-steroid hormone biosynthesis and metabolism | L | M |
| 2 | Alkaloid biosynthesis II | L | M |
| 2 | Biopterin metabolism | L | M |
| 3 | Glycerophospholipid metabolism | L | M |
| 3 | Glycosphingolipid metabolism | L | M |
| 3 | Histidine metabolism | L | M |
| 3 | Sialic acid metabolism | L | M |
| 3 | Glutathione Metabolism | L | M |
| 2 | Saturated fatty acids beta-oxidation | M | LM |
| 2 | Di-unsaturated fatty acid beta-oxidation | M | LM |
| 2 | Omega-3 fatty acid metabolism | M | LM |
| 2 | Dimethyl-branched-chain fatty acid mitochondrial beta-oxidation | M | LM |
| 2 | Linoleate metabolism | LM | M |