Table 2.

Change in opioid consumption and pain ratings from baseline: median difference (P values)

Outcomes	+1 Day	+2 Days	+3 Days	+1 Day After Discontinuation
MME†	−1.4 (0.5560)	−12.0 (0.6432)	9.7 (0.7545)	−12.0 (0.3655)
Numeric pain rating	−0.54 (0.0013)*	−0.34 (0.0121)*	−0.58 (0.0157)	−0.56 (0.0071)*

Median differences in opioid consumption (as measured by oral morphine milligram equivalents (MME) per day) scores and self-reported numeric pain rating (NPR) for each day compared to baseline (1 day before infusion start). Negative values indicate reduction, while positive values indicate increase. P values from Wilcoxon Signed-Rank Test. Median and confidence intervals (CI) are Hodges-Lehmann estimates for each day compared to baseline (one day before infusion start). With Bonferroni correction, P values are significant at P < .0125.

^*Statistically significant values (P < .0125).

^†MME = morphine milligram equivalents.