Table 3B.
Changes in numeric pain rating based on patient and infusion characteristics: median difference (confidence intervals)
| +1 Day (N = 50) | +2 Days (N = 43) | +3 Days (N = 36) | +1 Day After Discontinuation (N = 33) | |
|---|---|---|---|---|
| Patient characteristics | ||||
| Age† | −0.06 (−0.33, 0.21) | 0.03 (−0.26, 0.31) | 0.09 (−0.22, 0.39) | 0.06 (−0.25, 0.36) |
| Sex (females vs males) | −0.55 (−1.38, 0.23) | 1.07 (0.19, 2.15) | −0.35 (−1.30, 0.50) | −0.42 (−1.42, 0.67) |
| Health care utilization within one year (3+ vs <3 admissions) | 0.13 (−0.74, 1.02) | −0.07 (−1.12, 1.02) | 1.11 (0.22, 1.94) | 1.10 (0.08, 2.13) |
| Infusion characteristics | ||||
| Early vs late (≤3 of hospitalization or >3 of hospitalization) | −1.81 (−2.74, −0.84)* | −1.96 (−3.29, −0.78)** | −0.94 (−1.88, 0.21) | −1.19 (−2.35, −0.20) |
| Infusion duration (<24 hr vs >24 hr.) | −0.04 (−1.08, 1.00) | 0.65 (−0.73, 1.98) | 0.69 (−0.60, 1.98) | 0.04 (−1.22, 1.22) |
Changes in self-reported numeric pain rating (NPR) by subgroup. Negative values indicate reduction, while positive values indicate increase. P values from Wilcoxon Rank-Sum Test. Median and confidence intervals (CI) are Hodges-Lehmann estimates for each day compared to baseline (1 day before infusion start).
Estimate for age is Spearman rho correlation and 95% Fisher transformation confidence interval. With Bonferroni correction, P values are significant at P < 0.125.
Statistically significant values (P = .0003).
Statistically significant values (P = .0006).
† Spearman correlation coefficients with 95% Fisher's Transformation Confidence Intervals.