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. 2023 Feb 10;25:e41298. doi: 10.2196/41298

Table 2.

Overall global test results and between-group differences in maternal psychological distress in the generalized estimating equations analysis.

Outcomes and time Digital GSH-MBIa group, mean (SD) Control group, mean (SD) Estimated mean difference, mean (95% CI) P value Cohen d Group × time






Wald χ2 (df) P value
Depression 20.6 (5) .001

T1b 8.91 (3.54) 9.43 (3.26) −0.53 (−1.57 to 0.52) .33 N/Ac


T2d 5.21 (4.46) 7.86 (5.07) −2.64 (−4.12 to −1.16) <.001 0.56 (0.24 to 0.87)


T3e 4.48 (4.22) 8.60 (5.58) −4.22 (−5.79 to −2.66) <.001 0.84 (0.50 to 1.17)


T4f 5.81 (5.27) 9.25 (6.34) −3.23 (−5.10 to −1.37) .001 0.59 (0.26 to 0.92)


T5g 5.25 (4.47) 8.27 (6.31) −3.18 (−4.94 to −1.43) <.001 0.56 (0.23 to 0.90)


T6h 5.54 (5.44) 8.45 (6.53) −2.51 (−4.57 to −0.45) .02 0.49 (0.15 to 0.83)

Anxiety 24.7 (5) <.001

T1 5.56 (2.61) 5.80 (3.14) −0.24 (−1.13 to 0.65) .60 N/A


T2 3.14 (2.74) 5.61 (3.04) −2.46 (−3.36 to −1.56) <.001 0.85 (0.52 to 1.18)


T3 3.32 (3.19) 6.18 (3.83) −2.62 (−3.76 to −1.48) <.001 0.82 (0.48 to 1.15)


T4 4.49 (3.63) 7.31 (4.49) −2.74 (−4.04 to −1.44) <.001 0.69 (0.36 to 1.02)


T5 4.34 (3.31) 5.90 (4.71) −1.60 (−2.91 to −0.29) .02 0.39 (0.05 to 0.72)


T6 3.75 (3.28) 5.90 (4.76) −1.52 (−2.92 to −0.13) .03 0.53 (0.19 to 0.87)

Pregnancy-related anxiety 46.5 (2) <.001

T1 22.61 (4.53) 21.88 (4.64) 0.74 (−0.67 to 2.15) .31 N/A


T2 19.47 (4.03) 23.15 (5.55) −3.70 (−5.20 to −2.19) <.001 0.76 (0.43 to 1.08)


T3 19.41 (4.98) 24.22 (5.77) −4.92 (−6.60 to −3.23) <.001 0.89 (0.55 to 1.23)

aGSH-MBI: guided self-help mindfulness-based intervention.

bT1: baseline (12-20 weeks of gestation).

cN/A: not applicable.

dT2: immediately after the intervention (about 20-28 weeks of gestation).

eT3: before birth (36-37 weeks of gestation).

fT4: 6 weeks post partum.

gT5: 3 months post partum.

hT6: 6 months post partum.