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. Author manuscript; available in PMC: 2023 Feb 25.
Published in final edited form as: Sci Immunol. 2021 Oct 29;6(64):eabj1181. doi: 10.1126/sciimmunol.abj1181

Fig. 7. Vi PS antibodies mediate non-neutralizing Fc effector functions that are highly associated with slow antibody dissociation rates.

Fig. 7.

(A) ADMP scores and (B) ADCD scores for Vi binding mAbs (n = 53), where blue indicates antibodies that bind to subdominant exposed epitopes (SEE, n = 3) and pink indicates antibodies that bind to subdominant occluded epitopes (SEO, n = 3). (C) Spearman correlation of ADMP and ADCD scores for Vi mAbs (n = 53). (D) Spearman correlations of ADMP with antibody off-rate (left) and avidity (right). (E) Spearman correlations of ADCD with antibody off-rate (left) and affinity (right). Negative correlations represent decreases in off-rate and KD, which corresponds to increases in avidity.