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Classification of NSAIDs according to their selectivity for COX isoenzymes
| Category | Properties | Examples |
|---|---|---|
| 1 | Inhibitors of COX-1 and COX-2 | indomethacin, aspirin, diclofenac, naproxen, ibuprofen |
| 2 | 5- to 50-fold COX-2 selective | etodolac, meloxicam, celecoxib, nimesulide |
| 3 | > 50-fold COX-2 selective | diisopropyl fluorophosphate, L-745337, rofecoxib, NS398 |
| 4 | Weak inhibitors of COX-1 and COX-2 | 5-Aminosalicylic acid, nabumetone, sodium salicylate, sulfasalazine |
