Table 2.

Pathological and non-pathological systems featuring mitochondrial transfer

Condition		Result	Reference
Pathological	Lung carcinoma	Rescued mitochondrial function	Spees et al., 2006
	Osteosarcoma	Rescued mitochondrial function	Cho et al., 2012
	Acute lung injury	Cellular protection and tissue repair	Islam et al., 2012
	Ischemia	Preserving myocardial energetics, cell viability, and enhanced post-infarct cardiac function—protect the heart from ischemia-reperfusion injury	Masuzawa et al., 2013
	Allergic airway inflammation	Enhanced rescue of epithelial injury	Ahmad et al., 2014
	Chronic obstructive pulmonary disease	Attenuation of cigarette smoke–induced lung damage	Li et al., 2014
	Ischemia	Cardioprotection from ischemia-reperfusion injury	Cowan et al., 2016
	Cerebral ischemia	Amplified cell survival signals—neurorecovery	Hayakawa et al., 2016
	Acute respiratory distress syndrome	Enhancement of phagocytic activity of lung alveolar macrophages	Jackson et al., 2016a; Jackson et al., 2016b
	Acute myeloid leukemia	Resistance to chemotherapy	Moschoi et al., 2016
	Canine transmissible venereal tumor	Acquisition of functional mtDNA	Strakova et al., 2016, 2020
	Bladder cancer	Increased invasiveness	Lu et al., 20178
	Acute respiratory distress syndrome	Anti-inflammatory and highly phagocytic macrophage phenotype resulting in amelioration of lung injury	Morrison et al., 2017
	PD	Acquisition of functional mitochondria	Rostami et al., 2017
	Oxygen-glucose deprivation	Restoring brain endothelial energetics and barrier integrity	Hayakawa et al., 2018
	Hypoxia/reoxygenation injury	Attenuation of CM apoptosis	Shen et al., 2018
	Asthma	Alleviated asthmatic inflammation	Yao et al., 2018
	Diabetic nephropathy	Structural and functional restoration of renal proximal tubular epithelial cells	Konari et al., 2019
	MM	Enhanced mitochondrial metabolism, protumoral effect	Marlein et al., 2019
	Neonatal cardiomyopathy	Improvement of CM bioenergetics and viability in male rats exposed to pre-gestational diabetes	Louwagie et al., 2021
	Lung carcinoma	Enhancement of metastatic potential during tumor progression	Takenaga et al., 2021
	Cerebral ischemia	Increased neuronal survival and improved metabolism	Tseng et al., 2021
	Glioblastoma	Adaptation of non-tumor astrocytes to tumor-like metabolism and hypoxia conditions	Valdebenito et al., 2021
	AD	Increased transmitophagy of defective neuronal mitochondrial, potential alleviation of AD pathology and symptoms	Lampinen et al., 2022
Non-pathological	Cardiac homeostasis	Preserved metabolic stability and organ function	Nicolas-Avila et al., 2020
	White adipose tissue homeostasis	Metabolic homeostasis, impairment leads to obesity	Brestoff et al., 2021
	Metabolic preconditioning of the heart	Cardio-protection against lipotoxic or ischemic stresses elicited by obesity	Crewe et al., 2021
	Wound healing	Promotion of pro-angiogenic activity of MSCs via their metabolic remodeling	Levoux et al., 2021