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Schematic representation of the diversity of immunocytokine formats. (A) Immunocytokines based on full-scale IgG. (B) Intermediate-size immunocytokines. (C) Small-size immunocytokines based on antibody scFv or VHH fragments. (D) Conditionally activated immunocytokines. Abbreviations: VH and VL—heavy and light chain variable domains; CL—light chain constant domain; CH1, CH2, CH3—heavy chain constant domains; scFv—single chain variable fragment; VHH—single domain antibodies.
