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. 2023 Feb 14;222(4):e202204093. doi: 10.1083/jcb.202204093

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© 2023 Barad et al.

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Figure S10. — ER membrane curvature analysis. (A) Representative membrane surface reconstructions of the ER in MEF^mtGFP cells treated with vehicle and Tg (500 nM, 8 h) and associated with defined mitochondrial populations (elongated and fragmented). The ER surface is colored by membrane curvedness, and the OMM surface is represented as a transparent gray mesh. (B) Combined histograms of total ER curvedness of elongated (left) and fragmented (middle) mitochondria in MEF^mtGFP cells treated with vehicle and Tg. Dashed vertical lines correspond to peak histogram values of pooled data. Graph (right) showing peak histogram values from each ER membrane within each corresponding treatment and mitochondrial morphology class. Quantifications from vehicle elongated n = 9, Tg elongated n = 8, vehicle fragmented n = 3, and Tg fragmented n = 4 ER are shown.