Table 1.
Baseline characteristics of randomized participants.
| Treatment Groups | ||||
|---|---|---|---|---|
| Characteristic | All | Placebo | Low-Dose (0.01% Atropine) |
Loading Dose (0.1% to 0.01% Atropine) |
| N (%) | 97 | 32 (33.0) | 32 (33.0) | 33 (34.0) |
| Site, N (%) | ||||
| Copenhagen | 43 (44.3) | 14 (32.6) | 14 (32.6) | 15 (34.9) |
| Vejle | 41 (42.3) | 13 (31.7) | 14 (34.1) | 14 (34.1) |
| Aarhus | 13 (13.4) | 5 (38.5) | 4 (30.8) | 4 (30.8) |
| Female/Male (%) | 55/42 (57/43) | 18/14 (56/44) | 18/14 (56/44) | 19/14 (58/42) |
| Age, mean (SD), years | 9.4 (1.7) | 9.2 (1.6) | 9.4 (1.9) | 9.5 (1.5) |
| Race, N (%) | ||||
| White | 82 (84.5) | 29 (90.6) | 25 (78.1) | 28 (84.8) |
| Mixed race | 9 (9.3) | 3 (9.4) | 3 (9.4) | 3 (9.1) |
| Middle East | 3 (3.1) | ― | ― | ― |
| Asian | 2 (2.1) | ― | ― | ― |
| Black or African American | 1 (1.0) | ― | ― | ― |
| AL, mean (SD), mm | 24.48 (0.84) | 24.41 (0.90) | 24.56 (0.78) | 24.48 (0.86) |
| SE, mean (SD), D | −3.02 (1.27) | −3.07 (1.04) | −2.97 (1.13) | −3.0 (1.59) |
| CCT, mean (SD), µm | 546.8 (30.3) | 546.0 (35.1) | 546.4 (25.7) | 547.8 (30.3) |
| ACD, mean (SD), mm | 3.31 (0.24) | 3.32 (0.27) | 3.33 (0.26) | 3.28 (0.19) |
| Photopic pupil size, mean (SD), mm | 2.68 (0.33) | 2.64 (0.31) | 2.60 (0.30) | 2.80 (0.36) |
| Mesopic pupil size, mean (SD), mm | 4.24 (0.74) | 4.11 (0.74) | 4.17 (0.58) | 4.42 (0.84) |
| Distance BCVA, mean (SD), logMAR | −0.09 (0.06) | −0.09 (0.06) | −0.09 (0.05) | −0.08 (0.07) |
| Near BCVA, mean (SD), logMAR | −0.04 (0.09) | −0.03 (0.09) | −0.05 (0.09) | −0.04 (0.09) |
| Accom. amplitude, mean (SD), D | 14.5 (4.0) | 14.1 (4.4) | 14.3 (3.9) | 15.1 (3.6) |
| ChT, mean (SD), µm | 247.9 (66.2) | 244.0 (65.1) | 259.8 (66.7) | 240.2 (67.2) |
| IOP, mean (SD), mmHg | 16.1 (2.7) | 16.1 (2.5) | 15.8 (3.1) | 16.5 (2.7) |
Abbreviations: Accom. = accommodation; ACD = anterior chamber depth; AL = axial length; BCVA = best-corrected visual acuity; CCT = central corneal thickness; ChT = choroidal thickness; D = diopters; IOP = intraocular pressure; logMAR = logarithm of the minimum angle of resolution; N = number of participants; SE = spherical equivalent; SD = standard deviation; ― = not specified due to risk of unmasking.