Table 3.
Diagnostic performance of CECT and EOB-MRI observations with corresponding histopathologic abnormality
| LR-4 or 5 score as HCC | |||||||||||||
| Size | CECT | EOB-MRI | p-value | ||||||||||
| Se | Sp | NPV | PPV | Acc | Se | Sp | NPV | PPV | Acc | Se | Sp | ||
| overall | R1 | 80.9 (38/47) | 100 (4/4) | 30.8 (4/13) | 100 (38/38) | 82.4 (42/51) | 96.3 (78/81) | 85.7 (6/7) | 66.7 (6/9) | 98.7 (78/79) | 95.5 (84/88) | ||
| R2 | 69 (29/42) | 100 (4/4) | 23.5 (4/17) | 100 (29/29) | 71.7 (33/46) | 76.6 (59/77) | 83.3 (5/6) | 21.7 (5/23) | 98.3 (59/60) | 77.1 (64/83) | |||
| Pooled | 75.3 | 100 | 86.7 | 84.6 | < 0.001 | < 0.001 | |||||||
| < 2 cm | R1 | 81 (34/42) | 100 (2/2) | 20 (2/10) | 100 (34/34) | 81.8 (36/44) | 95.4 (62/65) | 80 (4/5) | 57.1 (4/7) | 98.4 (62/63) | 94.3 (66/70) | ||
| R2 | 64.9 (24/37) | 100 (2/2) | 13.3 (2/15) | 100 (24/24) | 66.7 26/39) | 73.4 (47/64) | 75 (3/4) | 15 (3/20) | 97.9 (47/48) | 73.5 (50/68) | |||
| Pooled | 73.4 | 100 | 84.5 | 77.8 | 1 | 1 | |||||||
| ≥ 2 cm | R1 | 80 (4/5) | 100 (2/2) | 66.7 (2/3) | 100 (4/4) | 85.7 (6/7) | 100 (16/16) | 100 (2/2) | 100 (2/2) | 100 (16/16) | 100 (18/18) | ||
| R2 | 100 (5/5) | 100 (2/2) | 100 (2/2) | 100 (5/5) | 100 (7/7) | 92.3 (12/13) | 100 (2/2) | 66.7 (2/3) | 100 (12/12) | 93.3 (14/15) | |||
| Pooled | 90 | 100 | 96.6 | 100 | 0.452 | 0.452 | |||||||
| LR-5 score as HCC | |||||||||||||
| size | CECT | EOB-MRI | p-value | ||||||||||
| Se | Sp | NPV | PPV | Acc | Se | Sp | NPV | PPV | Acc | Se | Sp | ||
| overall | R1 | 86.5 (32/37) | 100 (4/4) | 44.4 (4/9) | 100 (32/32) | 87.8 (36/41) | 54.2 (32/59) | 100 (7/7) | 20.6 (7/34) | 100 (32/32) | 59.1 (39/66) | ||
| R2 | 68.6 (24/35) | 100 (4/4) | 26.7 (4/15) | 100 (24/24) | 71.8 (28/39) | 50 (30/30) | 83.3 (5/6) | 14.3 (5/35) | 96.8 (30/31) | 53 (35/66) | |||
| Pooled | 77.8 | 100 | 52.1 | 92.3 | 0.243 | 0.243 | |||||||
| 1–1.9 cm | R1 | 87.5 (28/32) | 100 (2/2) | 33.3 (2/6) | 100 (28/28) | 88.2 (30/34) | 48.8 (21/43) | 100 (5/5) | 18.5 (5/27) | 100 (21/21) | 54.2 (26/48) | ||
| R2 | 70 (21/30) | 100 (2/2) | 18.2 (2/11) | 100 (21/21) | 71.9 (23/32) | 51.1 (24/47) | 75 (3/4) | 11.5 (3/26) | 96 (24/25) | 52.9 (27/51) | |||
| Pooled | 79 | 100 | 50 | 88.9 | 0.002 | 0.002 | |||||||
| ≥ 2 cm | R1 | 80 (4/5) | 100 (2/2) | 66.7 2/3) | 100 (4/4) | 85.7 (6/7) | 68.8 (11/16) | 100 2/2) | 28.6 (2/7) | 100 (11/11) | 72.2 (13/18) | ||
| R2 | 60 (3/5) | 100 (2/2) | 50 (2/4) | 100 (3/3) | 71.4 (5/7) | 46.2 (6/13) | 100 (2/2) | 22.2 (2/9) | 100 (6/6) | 53.3 8/15) | |||
| Pooled | 70 | 100 | 58.6 | 100 | 1 | 1 | |||||||
Data are percentages, with numerators and denominators in parentheses
Acc accuracy, CECT contrast-enhanced computed tomography, EOB-MRI Gadoxetic acid-enhanced MRI, NPV negative predictive value, PPV positive predictive value, R1 reader 1, R2 reader 2, Se sensitivity, Sp specificity