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. 2023 Feb 25;21:153. doi: 10.1186/s12967-023-04009-6

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — LINC00543 blocks the maturation of miR-506-3p. a The expression of miR-506-3p, pre-miR-506-3p, and ppi-miR-506-3p in SH cells. b The relationship between the expression of LINC00543 and Pre-miR-506-3p. c The relationship between the expression of LINC00543 and the expression of miR-506-3p. d The binding regions of LINC00543 to pre-miR-506-3p. e RAP analysis of the expression of pre-miR-506-3p in SH cells. f The expression of pre-miR-506-3p in the nucleus and the cytoplasm in SH cells. g Illustrative model showing that LINC00543 blocked the transportation of pre-miR-506-3p. h RIP analysis of the interaction between XPO5 and pre-miR-506-3p in SH cells. i RIP analysis of the interaction between XPO5 and LINC00543 in SH cells. j Schematic diagram of biotin segment probes. k RAP analysis of the interaction between four segments of LINC00543 and pre-miR-506-3p. l RIP analysis of the interaction between XPO5 and pre-miR-506-3p in cells incubated with antisense nucleotide biotin probes of the three binding regions. m and n The interaction between LINC00543, XPO5, and pre-miR-506-3p were analyzed in cells incubated with the antisense nucleotide biotin probes of the three binding regions