Figure 2.

Main cells populating the tumor microenvironment, i.e., monocyte-derived macrophages (MoMϕs) differentiating into tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), tumor-associated neutrophils (TANs), natural killer cells (NKs), regulatory T cells (Tregs), and cytotoxic CD8+ T (Teffector), as well as cancer-associated fibroblasts (CAFs), hepatic stellate cells (HSCs), and endothelial cells. TP53 and CTBBN1 are the two genes most frequently mutated showing a correlation with TMB.