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. 2023 Feb 25;22:41. doi: 10.1186/s12933-023-01765-z

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Changes During Low-calorie Diet and From Randomization to Week 52. Per-protocol analysis of mixed model estimated changes in metabolic syndrome severity z-score (A), metabolic syndrome prevalence (B), android fat percentage (C), and high-sensitivity C-reactive protein (D) during a low-calorie diet (shaded area; weeks -8 to 0) and treatment (weeks 0 to 52). Changes are estimated mean differences with ± standard error of the mean. Changes in high-sensitivity C-reactive protein are presented as percentages via ratios from back-transformed log-data and shown with 95% confidence intervals. Between-group changes are estimated mean differences with 95% confidence intervals and p-values. Results are adjusted for age group (< / ≥ 40 years) and sex. Dashed line is the baseline for the low-calorie diet and randomized groups (at week 0)