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Antidepressant-like effects of (R)-ketamine co-administered with LY341495 (mixRL) in the CUMS model of depression in mice. (A) Effect of mixRL on the exploratory behavior in the NCT; (B) effect of mixRL on the immobility time in the FST. The values are expressed as the means ± SEM and were analyzed by two-way ANOVA. * p < 0.05, **** p < 0.0001 CUMS main effect; # p < 0.05 CUMS × drug interaction (N = 8–10). mixRL—(R)-ketamine 1 mg/kg + LY 341495 0.3 mg/kg.
