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. 2023 Feb 14;16(2):288. doi: 10.3390/ph16020288

Figure 4.

Figure 4

Effect of (R)-ketamine (1 mg/kg) co-administered with LY341495 (0.3 mg/kg) (mixRL) in the CUMS model of depression on field potential (FP) recording, paired-pulse stimulation, and LTP induction. (A) Effects of veh, CUMS, and mixRL treatment on the relationship between stimulus intensity and the amplitude of FPs (mean ± SEM) recorded in slices originating from veh animals (white circles, N = 24), stressed animals (CUMS; black circles, N = 17), and mixRL animals (green circles, N = 24); (B) differences in maximal FPs amplitudes between veh, CUMS, and mixRL groups; (C) raw waveforms of individual FPs evoked by paired stimuli in slices from veh (white circles), after CUMS (black circles) and mixRL (green circles) animals; (D) differences in FP2/FP1 between veh, CUMS, and mixRL groups; (E) effects of CUMS and mixRL on LTP; plot of the amplitude of FPs (mean ± SEM) recorded in the veh group (white circles, N = 24), stressed group (CUMS; black circles, N = 17), and mixRL (green circles, N = 20); the arrow denotes the time of the beginning of TBS; insets show the superposition of averaged FPs recorded in representative experiments at the times indicated by numbers; (F) comparison of the CUMS and mixRL evoked changes in LTP magnitude. The values are expressed as the means ± SEM and were analyzed by one-way ANOVA followed by post hoc Tukey’s multiple comparisons test. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. veh or CUMS, respectively.