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. 2023 Feb 24;21:72. doi: 10.1186/s12916-023-02738-5

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Waterfall plot of systemic BOR (A) and forest plot of systemic objective response in subgroups (B). Response was assessed by IRC in the FAS (the same as the PPS). The dashed lines at 20% and -30% indicate the thresholds for PD and PR, respectively. There were nine and four patients with IRC-assessed BOR of non-CR/non-PD and NE, respectively. BOR, best objective response; CR, complete response; PR, partial response. SD, stable disease. PD, progressive disease. ORR, objective response rate. DCR, disease control rate. IRC, independent review committee. NE, not evaluable. FAS, full analysis set. PPS, per-protocol set