Table 3.
COMPARE analysis of Breastin vs. 153 anticancer agents with known mechanisms in the Oncotest panel of 74 tumor cell lines.
| No. | R-Value | p-Value | Standard Agent | Mode of Action | Mode of Action |
|---|---|---|---|---|---|
| IC50-Based Spearman Rank Correlation | |||||
| 1 | 0.576 | 0.0014 | VER-49009 | Heat shock protein 90 inhibitor | |
| 2 | 0.492 | 0.0081 | 4-Hydroperoxy-ifosphamide | Alkylating agent | |
| 3 | 0.429 | 0.0230 | GSK461364A | PLK1 inhibitor | Mitosis-related |
| 4 | 0.390 | 0.0403 | MST-312 | Telomerase inhibitor | |
| 5 | 0.381 | 0.0453 | BI2536 | PLK1 inhibitor | Mitosis-related |
| 6 | 0.378 | 0.0470 | Thiotepa | Alkylating agent | |
| 7 | 0.376 | 0.0488 | BI 6727 3 HCl | PLK1 inhibitor | Mitosis-related |
| IC70-Based Spearman Rank Correlation | |||||
| 1 | 0.487 | 0.0087 | Vinorelbine bistartrate | Tubulin inhibitor | Mitosis-related |
| 2 | 0.470 | 0.0112 | 4-Hydroperoxy-ifosphamide | Alkylating agent | |
| 3 | 0.455 | 0.0151 | VER-49009 | Heat shock protein 90 inhibitor | |
| 4 | 0.446 | 0.0176 | Ispinesib, mesylate | Eg5 inhibitor | Mitosis-related |
| 5 | 0.428 | 0.0230 | Methotrexate hydrate | Antimetabolite | |
| 6 | 0.424 | 0.0246 | Vindesine sulfate | Tubulin inhibitor | Mitosis-related |
| 7 | 0.415 | 0.0282 | BI6727 3HCl | PLK1 inhibitor | Mitosis-related |
| 8 | 0.404 | 0.0333 | BI2536 | PLK1 inhibitor | Mitosis-related |
| 9 | 0.395 | 0.0374 | Vincristine sulfate | Tubulin inhibitor | Mitosis-related |
| 10 | 0.395 | 0.0377 | Vinflunine di-tartrate | Tubulin inhibitor | Mitosis-related |
| 11 | 0.391 | 0.0394 | Purvalanol A | CDK inhibitor | |
| 12 | 0.389 | 0.0409 | Suberic bis-hydroxamic acid | HDAC inhibitor | |
| 13 | 0.380 | 0.0463 | Bleomycin sulfate | DNA synthesis inhibitor | |
| 14 | 0.380 | 0.0460 | GSK461364A | PLK1 inhibitor | Mitosis-related |