Fig. 5. Effects of loss of FXR on lung macrophages responding to NM.
Lung macrophages were collected 3 d, 14 d, and 28 d after administration of PBS (CTL) or NM to male wild-type (WT) and FXR−/− mice. Cells were immunostained with antibodies to CD45, CD11b, Ly6C, Ly6G, F4/80, and CD11c or isotypic controls and analyzed by flow cytometry. Bars, mean ± SE (n = 5–9 mice/treatment group). Y-axis, macrophages/10,000 viable BAL cells. *Significantly different (p ≤ 0.05) from CTL treated mice. #Significantly different (p ≤ 0.05) from WT mice.