Fig. 6. Effects of loss of FXR on NM-induced increases in expression of COX-2 and ARL11.

Lung sections prepared 14 d and 28 d after administration of PBS (CTL) or NM to male wild-type (WT) and FXR^−/− mice were immunostained with antibodies to COX-2 and ARL11. Binding was visualized using a peroxidase DAB substrate kit. Arrows indicate lung macrophages. Representative sections from 3–5 mice/treatment group are shown. Original magnification, 40×.