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. 2023 Jan 25;15(2):406. doi: 10.3390/pharmaceutics15020406

Table 2.

Characterization of the peptide derivatives and polymer-peptide constructs.

Sample Structure Precursor Peptide *
wt%		 Dye # wt% Mw X
g‧mol−1 		Đ X DH XX
nm
PEP GKWMKLLKKILK-NH2 N/A 100 0 N/A N/A N/A
F-PEP ATTO-488-GKWMKLLKKILK-NH2 N/A 72.2 27.8 N/A N/A N/A
P p(HPMA) N/A 0 0 40,000 1.06 5.9
P-PEP p(HPMA-co-Ma-β-Ala-DBCO-azide-PEP) 2 11.0 0 44,800 1.08 12.6
F-P p(HPMA-co-Ma-β-Ala-ATTO-488) 2 0 2.0 40,000 1.06 8.2
F-P-PEP p(HPMA-co-Ma-β-Ala-ATTO-488-co-Ma-β-Ala-DBCO-azide-PEP) 4 11.5 1.6 46,300 1.12 n.d.
P-ValCit-PEP p(HPMA-co-Ma-β-Ala-DBCO-ValCit-PEP) 2 10.0 0 43,300 1.12 12.2
P-LAAG-PEP p(HPMA-co-Ma-β-Ala-DBCO-LAAG-PEP) 2 12.8 0 42,000 1.08 11.2
P-GFLG-PEP p(HPMA-co-Ma-β-Ala-DBCO-GFLG-PEP) 2 11.0 0 41,200 1.09 11.0
P-Hyd-PEP p(HPMA-co-Ma-Acap-NHN=levulinyl-PEP) 3 14.8 0 45,500 1.18 12.6

* Calculated using amino-acid analysis. # Determined by UV-vis in methanol (ε505 = 90,000 L·mol−1·cm−1). X Molecular weights were determined by SEC using RI and LS detection. XX DH was measured using DLS (in PBS buffer at 25 °C). N/A non-applicable. n.d. non-determined.