. 2023 Feb 5;24(4):3144. doi: 10.3390/ijms24043144

Table 10.

Kinetic parameters of nucleoside transporters of T. brucei brucei, T. congolense and T. vivax.

Transporter	Substrate
Transporter	ADE	ADO	GUA	GUO	HYP	INO	CTD	TMD	URD
TbP2/AT1	0.38 ^a; 0.30 ^c	0.59 ^a; 0.92 ^c		NE ^3,c	>500 ^c	NE ^4,c	NE ^3,c	NE ^2,c	NE ^2,c
TbP1/NT2	NE ^3,c	0.15 ^a; 0.26 ^b; 0.38 ^c		1.8 ^c	NE ^1,c	0.44 ^c	NE ^3,c	44 ^c	830 ^c
TbNT5 ^d		2	2.2		49.4
TbNT6 ^d		1.4	4.3
TbNT7 ^d		0.3	1.8
TbNT9 ^e	148	0.068		6.2	320	2.75		510	235
TbNT10 ^e		0.41				0.53
TbNT11 ^f	2.7; 8	266	651		141
TbNT8/H4 ^g	2.6	860	2.6	4.7	0.55	20			95
TcoAT1	786	0.42		0.80	61.2	0.55	1630	49.6	147
TvxNT3	2.43	1.41		1.37	1.75	0.086	>100	603	720

Values in bold represent K_m values; all others are K_i values. ADE, adenine; ADO, adenosine; GUA, guanine; GUO, guanosine; HYP, hypoxanthine; INO, inosine; CTD, cytidine; TMD, thymidine; URD, uridine; NE, no effect at ¹ 1 mM, ² 500 μM, ³ 250 μM, ⁴ 100 μM. ^a Carter and Fairlamb [41]; ^b De Koning et al. [34]; ^c De Koning and Jarvis [44]; ^d Sanchez et al. [39]; ^e Al-Salabi et al. [40]); ^f Ortiz et al. [96]; ^g Burchmore et al. [70]. Data for T. congolense (Tco) and T. vivax (Tvx) transporters were from this study. NE, no effect at the stated concentration.