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. 2023 Feb 6;24(4):3237. doi: 10.3390/ijms24043237

Figure 2.

Figure 2

Transcriptome characteristics of DOX-treated MDA-MB-231 compared to non-treated samples from three independent experiments. (A) The multidimensional scaling (MDS) plot of MDA-MB-231 RNA-seq samples at days 0 (non-treated, NT), 5, 8, 16, and 22 post-DOX treatment showing (by dashed outline) the separation of the sampled cohorts, with the cohorts on day 22 returning to the NT pattern. (B–E) Volcano plots of differentially expressed (DE) genes (FDR < 0.05, |LogFC| > 1) on: (B) day 5 versus NT; (C) day 8 versus NT; (D) day 16 versus NT; (E) day 22 versus NT. (F) The proportions of bivalent genes amongst DE genes, up-and downregulated, respectively, on days 5, 8, 16, and 22 post-DOX.