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. 2023 Feb 6;12(2):261. doi: 10.3390/pathogens12020261

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Gene expression in the HCLE cells treated with the control and PED patients, the STRIN network analysis, and the correlation plot. Error bars represent standard error of means. A t-test was performed (* implies significantly different, p < 0.05), IL1B—Interleukin 1-beta; IL6—Interleukin 6; Il8—Interleukin 8; TGFB1—Transforming growth factor-beta (TGFβ) 1; TGFB2—Transforming growth factor-beta 2; IRF3—Interferon regulatory factor 3; STING—Stimulator of interferon genes; TNFA—Tumor necrosis factor-alpha. mRNA level changes in the HCLE cells as detected by qRT-PCR (A). Error bars represent standard error of mean. DSG—desmoglein, b-Catenin—beta Catenin; KLF4—Kruppel-like factor 4, GPX4—Glutathione peroxidase 4, NCOA4—Nuclear Receptor Coactivator 4; SLC7A11—Solute Carrier Family 7 Member 11 (B). The STRING analysis of the same gene dataset used to identify the interactions with other genes (C). Correlation plot showing positive and negative correlation with each other (D).