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. 2023 Feb 15;13(2):335. doi: 10.3390/jpm13020335

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of Canrenoic Acid on Potassium Channels. (A) Raw traces of K⁺ currents at +40 mV in control (black), DSC2 (red), and DSC2 + CA (green) condition and (B) potential current curves corresponding (CTRL n = 12; DSC2 n = 15; DSC2 + CA n = 10). (C) Raw traces of K⁺ currents at +40 mV in control (black), DSC2 (red), and DSC2 + SP (blue) condition and (D) potential current curves corresponding (CTRL n = 12; DSC2 n = 15; DSC2 + SP n = 11). (E) Values of Current amplitude at 40 mV for the different groups. (F) RT-qPCR results of fold change expression for hERG and KCNQ1 gene in CTRL and DSC2 hiPSC−CM. The results are represented with the median and 95% confidence interval. The stars * correspond to the difference from the control. ns not statically significant, * p < 0.05, ** p < 0.01 (Kruskal–Wallis test).

Effect of Canrenoic Acid on Potassium Channels. (A) Raw traces of K⁺ currents at +40 mV in control (black), DSC2 (red), and DSC2 + CA (green) condition and (B) potential current curves corresponding (CTRL n = 12; DSC2 n = 15; DSC2 + CA n = 10). (C) Raw traces of K⁺ currents at +40 mV in control (black), DSC2 (red), and DSC2 + SP (blue) condition and (D) potential current curves corresponding (CTRL n = 12; DSC2 n = 15; DSC2 + SP n = 11). (E) Values of Current amplitude at 40 mV for the different groups. (F) RT-qPCR results of fold change expression for hERG and KCNQ1 gene in CTRL and DSC2 hiPSC−CM. The results are represented with the median and 95% confidence interval. The stars * correspond to the difference from the control. ns not statically significant, * p < 0.05, ** p < 0.01 (Kruskal–Wallis test).