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Schematic diagram of a benefits effects of Spironolactone on ACM-hiPSC-CM. HiPSC-CMs harboring a desmosomal mutation allow one to decipher the ACM disease. The electrophysiological and calcium-handling properties disturbed in this pathology. Application of Spironolactone prevents these effects, by a normalization of Action potential duration, electrical stability and a calcium handling restored. Spironolactone can reduce the risk of ventricular arrhythmias in ACM patients.
