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. 2023 Feb 14;10:rbad011. doi: 10.1093/rb/rbad011

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© The Author(s) 2023. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Se-Modified bone cement improved the osteoporotic bone defect repair in OVX rats. Defects of lateral femoral condyle in OVX rats were repaired using bone cement with or without Na₂SeO₃. (A, C) After 4 and 8 weeks of surgery, micro-CT analysis was used to evaluate the osteoporotic bone defect repair. The red areas represent the new bone, and the gray areas represent the remaining material. (B) Quantitative analysis of BV/TV at the time points of 4 and 8 weeks. n = 3. (D) Representative histological images of rat femurs using hematoxylin eosin (H&E), and masson staining. Scale bar = 100 μm. (E) Representative immunohistochemical staining of the expression of GPx1 around the bone defects. Scale bar = 100 μm. Values represent mean ± SEM. Statistically significant differences are indicated by * where P < 0.05 or ** where P < 0.01 between the indicated groups.