Table 1.

Suggested benefits from metformin use due to its pleiotropic effects.

Indication for Metformin Treatment	Benefits from Metformin Use Due to Its Pleiotropic Effects	References
Diabetes mellitus type II	Obesity Cardiovascular protection Polycystic ovarian syndrome d Musculoskeletal diseases—osteopenia, osteoporosis, osteoarthritis Cancer Aging	[27,29,37,38]