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. 2023 Feb 16;15(2):551. doi: 10.3390/v15020551

Figure 3.

Figure 3

Quantitative immunohistochemical analysis of selected endothelial cell markers in zones Z3, Z2, Z1 and PT in hepatic parenchyma of squirrel monkeys (Saimiri spp.) infected with YFV. Circles represent areas expressing higher immunostaining cells in different hepatic areas. (A) Expression of VCAM-1. (D) Immunostaining for VCAM-1 in the inflammatory infiltrate (D-Z3), in Kupffer cells (D-Z2), (D-Z1) and bile duct (D-PT). (B) Expression of ICAM-1. (E) Immunostaining for ICAM-1 in hepatocytes (E-Z3), (E-Z2), (E-Z1) in Kupffer cells, (E-PT) in the bile duct. (C) VLA-4 expression. (F) Immunostaining for VLA-4 in endothelial and Kupffer (F-Z3) cells, (F-Z2) in inflammatory infiltrate, (F-Z1), (F-PT) in 6 dpi bile duct.