Figure 7.

Integrated network and possible mechanism of in situ immune response in the hepatic parenchyma of non-human primates (Saimiri spp.) infected with the yellow fever virus. After the infection, YFV is recognized by dendritic cells (DC), initiating the immune response by triggering immune cells that will produce the mechanisms to activate different local cells in liver and the production of cytokines and chemokines to drive the organism defenses. Both innate and adaptive immune cells have an important role in triggering the adequate response and the Treg cells are directly involved in the regulation of an equilibrated immunologic response in efforts to control the damage caused by YFV in the hepatic tissue.