Table 5.
List of the papers focused on bacterial cellulose based composites functionalised with GO(rGO) for wound healing application.
| Year | Material | Cellulose Biosource | GO Processes | Crosslinker/ Gelling Agents |
Inorganic/Organic Compounds Embedded |
Physico- Chemical and Mechanical Properties |
In Vitro Outcomes | In Vivo Outcomes |
Ref. |
|---|---|---|---|---|---|---|---|---|---|
| 2019 | rGO/Ag/DOPA/BC | Gluconacetobacter xylus (MTCC7795) | Hummers method | -- | AgNO3 | σtens = 1–5.52 ± 0.07 MPa σtens = 5.21 ± 0.03 MPa (Ag NPs effect) Average resistance of 84 kΩ |
E. coli inhibition zone diameter 15 ± 1 mm; P. aeruginosa inhibition zone diameter 11 ± 0.5 mm, S. aureus inhibition zone diameter 13 ± 0.5 mm, L. fusiformis inhibition zone diameter 14 ± 0.75 mm. High stimulation of NIH3T3 proliferation favouring the wound closure (18 h). |
- | [12] |
| 2019 | GO-CuO/BC | Gluconacetobacter xylinus (traditional Chinese drink) | CuO |
S. aureus inhibition zone diameter 16.3–18.3 mm; E. coli inhibition zone diameter 12.7–15.2 mm, B. subtilis inhibition zone diameter 27.8–28.5 mm, P. aeruginosa inhibition zone diameter 0–15.2 mm. NIH3T3 viability > 100% |
- | [146] | |||
| 2021 | rGO/Ag-pDA/BC | Gluconacetobacter xylinus | Hummers method | AgNO3 | E. coli inhibition zone 6.3 mm (AgNO3 effect) | - | [147] | ||
| 2022 | GQDs/BC | Komagataeibacter oboediens (IMBG180) | - | Bacterial inhibition against S. aureus, MRSA, E. coli, P. aeruginosa and S. agalactiae. Bactericidal effect against MRSA, E. coli and P. aeruginosa. Angiogenesis stimulation validated by up-regulation of eNOS, VEGFA, MMP-9 and vimentin |
[148] | ||||
| 2022 | GO/PVA/BC | - | TEOS PVA |
Cur | Increase of the compressive stress and hydrophilicity by increasing the GO content | E. coli inhibition zone 5–15 mm; S. aureus inhibition zone 7.5–16 mm; P. aeruginosa inhibition zone 7–17 mm | [3] |
Abbreviations: BC, bacterial cellulose; DOPA, dopamine; AgNO3, silver nitrate; NIH3T3, mouse embryonic fibroblast cell line; CuO, copper oxide; pDA, polydopamine; GQDs, graphene oxide quantum dots; MRSA, Methicillin-Resistant Staphylococcus Aureus; TEOS, Tetraethyl orthosilicate.