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. 2023 Jan 17;14(2):52. doi: 10.3390/jfb14020052

Figure 1.

Figure 1

Synthesis of fluorescent dye PBC by the reaction of citric acid using precursor 2-Amino phenol. Molecular weights for PCL-PEG-PBC and CA-PBC are 11,849 and 55,853 respectively. Scheme (i): CA conjugated PBC with catalyst DCC and DMAP at 180 °C. Scheme (ii): PCL-PEG conjugated PBC with catalyst DCC and DMAP at 180 °C. DCC: N,N′-dicyclohexylcarbodiimide; DMAP: 4-dimethyl aminopyridine; DMF, dimethyl formamide. Nanoparticles of CA and PCL-PEG conjugated with a fluorescent dye were prepared by the oil-in-water emulsion technique to deliver high- and low-solubility 4-AP and IND drug molecules.