. 2023 Jan 17;14(2):52. doi: 10.3390/jfb14020052

Table 2.

Drug release kinetics of IND and 4-AP from respective samples fit the Higuchi and Korsmeyer–Peppas drug release models. Higuchi models for both drug loading formulations show r² values near unity indicative of a strong correlation to diffusion-controlled release mechanisms. Similarly, the n values ranged between 0.46 and 0.69, with correlation coefficients ranging from 0.93 to 0.99 indicating that the drug release deviated slightly from the Fickian transport.

Nanoparticles	Higuchi Model		Kinetic Model (Korsmeyer–Peppas)
Nanoparticles	k	r²	n	r²
CA-PBC-IND	4.0531	0.9133	0.5683	0.9606
CA- IND	2.5749	0.9689	0.6023	0.9538
PCL-PEG-PBC-IND	5.1732	0.9877	0.6823	0.9732
PCL-PEG-IND	5.8024	0.9951	0.6893	0.9743
CA-PBC-4-AP	3.9342	0.9908	0.4741	0.9867
CA-4-AP	2.490	0.9949	0.4646	0.9929
PCL-PEG-PBC-4-AP	8.062	0.9233	0.4804	0.9372
PCL-PEG-4-AP	6.0567	0.9699	0.6988	0.9983

Higuchi model: $\frac{M_{t}}{M_{0}} = K t^{1 / 2}$ , Korsmeyer–Peppas: $\frac{M_{t}}{M_{\infty}} = k t^{n} .$