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. 2023 Feb 14;24(4):3807. doi: 10.3390/ijms24043807

Figure 6.

Figure 6

The effects of febuxostat on intrarenal MDA, SOD activity, and immunohistochemical staining for 8-OH-dG in STZ-induced diabetic mice. (a) Concentrations of the lipid peroxidation marker MDA in mouse kidneys. * p < 0.05 and ** p < 0.01 vs. Cont, † p < 0.05 and †† p < 0.01 vs. Feb, and ‡‡‡ p < 0.001 vs. STZ group. (b) SOD activity in mouse kidneys. ** p < 0.01 and *** p < 0.001 vs. Cont, † p < 0.05 vs. Feb, and ‡‡ p < 0.01 vs. STZ group. (c) Representative images and quantitative analyses for SOD1/GAPDH and SOD2/GAPDH, ** p < 0.01 vs. Cont, †† p < 0.01 vs. Feb and ‡‡ p < 0.01 vs. STZ group. (d) Representative immunohistochemical staining and semiquantitative analysis for 8-OH-dG in mouse kidneys (original magnification 400×). *** p < 0.001 vs. other groups.