Table 2.

Antitubercular activity in MIC in μM (μg/mL) of compounds 8a–p

Compound	R	R1	M. tuberculosis, H37 RV
8a	H	Methyl	14.4 (3.12)
8b	H	Ethyl	27.1 (6.25)
8c	H	n-Propyl	102 (25)
8d	H	n-Butyl	24.1 (6.25)
8e	Br	Methyl	21.2 (6.25)
8f	Br	Ethyl	20.2 (6.25)
8g	Br	n-Propyl	19.3 (6.25)
8h	Br	n-Butyl	9.2 (3.12)
8i	Cl	Methyl	24.9 (6.25)
8j	Cl	Ethyl	47.2 (12.5)
8k	Cl	n-Propyl	22.4 (6.25)
8l	Cl	n-Butyl	42.7 (12.5)
8m	F	Methyl	106.4 (25)
8n	F	Ethyl	401.6 (100)
8o	F	n-Propyl	190.1 (50)
8p	F	n-Butyl	180.5 (50)
Pyrazinamide			25.34 (3.12)
Isoniazid			11.67 (1.6)