Table 4.

LME analysis of SCR during trace fear recall

	CS presentation			Trace interval			US time point
Fear recall SCR	F value	df	p-value	F value	df	p-value	F value	df	p-value
Drug (doxycycline/placebo)	0.53	1, 94.19	0.468	2.13	1, 89.52	0.148	1.50	1, 1173.40	0.220
Condition (CS+/CS−)	5.55	1, 2774.23	0.019	5.57	1, 2770.09	0.018	0.56	1, 2745.20	0.455
Trial number	13.55	1, 94.11	>0.001*	38.35	1, 89.51	>0.001*	23.77	1, 2743.00	>0.001*
Drug × Condition	0.02	1, 2774.23	0.889	1.66	1, 2770.09	0.198	0.10	1, 2745.20	0.749
Drug × Trial	0.72	1, 94.11	0.397	1.58	1, 89.51	0.212	1.86	1, 2743.00	0.173
Condition × Trial	2.18	1, 2774.86	0.140	0.86	1, 2771.01	0.353	0.00	1, 2746.80	0.999
Drug × Condition × Trial	0.01	1, 2774.86	0.920	0.11	1, 2771.01	0.737	0.15	1, 2746.80	0.699

Models are estimated with lme4, lmer(data ∼ (1+trial|subject) + group*condition*trial) for CS and US time point and lmer(data ∼ (1|subject) + group*condition*trial) for trace interval, significant (p < 0.05) effects are marked with a * after Holm–Bonferroni correction.