Table 2.

Centralized clinical studies performed on the effect of intermittent hypoxia–hyperoxia on various pathologies.

Authors	Country	Year	Study Design	No. pac incl	References
Glazachev et al.	Russia	2017	non-randomized controlled before-and-after trial	46	21
Bayer et al.	Austria	2017	double-blind, randomized, stratified and placebo-controlled study	34	46
Dudnik et al.	Russia	2018	randomized controlled trial	28	16
Tuter et al.	Russia	2018	single-center, randomized controlled trial	120	29
Serebrovska et al.	Ukraine	2019	a pilot study	21	73
Bayer et al.	Austria	2019	double-blind, randomized controlled clinical trial	34	46
Bestavashvili et al.	Russia	2021	single-center, single-blind, randomized controlled trial	65	36
Chen et al.	Taiwan	2022	randomized, double-blind study	11	53
Behrendt et al.	Germany	2022	randomized, two-armed, controlled and single-blinded trial	28	164

Abbrev: No. pac incl—number of patients included.