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. 2023 Feb 16;24(4):4022. doi: 10.3390/ijms24044022

Figure 6.

Figure 6

Blocking the signal transduction of the CaN/NFAT1 signaling axis protected chondrocytes from anabolic/catabolic imbalance. (a,b) mRNA levels of Aggrecan, COL2A1, MMP3, and MMP13 in chondrocytes determined by RT-qPCR (n = 3). (c) Immunofluorescence staining and quantified results of MMP3, MMP13, Aggrecan, and COL2A1 in chondrocytes (n = 3). ** p < 0.01 vs. NC; # p < 0.05 vs. strain; ## p < 0.01 vs. strain;. Scale bar: 100μm. One-way ANOVA with Bonferroni’s test for (a–c), Kruskal–Wallis test with Dunn’s multiple comparisons test for COL2A1 in (b).