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. 2023 Feb 16;24(4):4022. doi: 10.3390/ijms24044022

Figure 7.

Figure 7

Intra-articular injections of Gsmtx4 ameliorated OA in rats. (a) Schematic illustration of Gsmtx4 injection in the ACLT-induced OA rat model. (b) HE, Safranin-O/Fast Green, and TUNEL stains of articular cartilage (n = 5). (c) The OARIS scores and the percentage of TUNEL positive cells of the cartilage (n = 5). (d) Immunohistochemistry staining of Aggrecan, COL2A1, MMP3, and MMP13 in articular cartilage, and (e) percentage of positive cells (n = 5). ** p < 0.01 vs. Sham; # p < 0.05 vs. ACLT; ## p < 0.01 vs. ACLT; & p < 0.05 vs. L-Gsmtx4; && p < 0.05 vs. L-Gsmtx4. One-way ANOVA with Bonferroni’s test for (c,e), Kruskal–Wallis test with Dunn’s multiple comparisons test for OARSI score in (c). Scale bar: 100 μm.