. 2023 Jan 19;11(2):93. doi: 10.3390/toxics11020093

Table 2.

Data recorded from the behavioral test for the mechanical threshold (dynamic test), neurophysiology, DRG morphometry, and IENFD (intraepidermal nerve fiber density) quantifications, at baseline and at end of treatments with vehicles and chemotherapies. Statistical analyses are also reported.

Tests	Parameters Evaluated		Baseline		End of Treatment		Baseline		End of Treatment		Statistical Analysis
Tests	Parameters Evaluated		VEH_PTX	PTX	VEH_PTX	PTX	VEH_CDDP	CDDP	VEH_CDDP	CDDP
DYNAMIC TEST	MECHANICAL THRESHOLD	mean	30.12	29.87	31.1	27.17 ***	29.94	30.81	31.59	32.62	*** p < 0.0001 vs VEH _PTX end treatment
	(grams)	SD	2.194	2.695	1.255	0.5398	2.349	2.059	3.335	4.808	Non parametric t test, Mann Whitney
		St. error	0.6615	0.7781	0.3785	0.1627	0.6781	0.5943	0.9627	1.388
NEUROPHYSIOLOGY	PROXIMAL CAUDAL NERVE AMPLITUDE	mean	122.3	124.5	171	56.64 ***	148	142	99.35	90.09	*** p = 0.0001 vs VEH _PTX end treatment
	(micronVolt)	SD	25.22	19.57	36.04	42.16	32.12	18.1	16.03	11.31	Non parametric t test, Mann Whitney
		St. error	7.282	5.649	10.41	12.17	9.272	5.224	4.627	3.265
	PROXIMAL NERVE SENSORY VELOCITY	mean	36.6	36.31	41	35.17 **	43.73	42.31	42.52	42.43	** p = 0.0016 vs VEH _PTX end treatment
	(meters/second)	SD	2.365	1.665	2.655	4.756	3.03	3.889	1.883	2.517	Non parametric t test, Mann Whitney
		St. error	0.6828	0.4807	0.7665	1.373	0.8747	1.123	0.5435	0.7267
	PROXIMAL DIGITAL NERVE AMPLITUDE	mean	87.38	96.46	136.7	100.9 **	95.13	90.79	116	110.8	** p = 0.0011 vs VEH _PTX end treatment
	(micronVolt)	SD	27.8	24.43	19.32	19.65	12.85	11.24	19.96	33.52	Non parametric t test, Mann Whitney
		St. error	8.026	7.053	5.578	5.673	3.709	3.244	5.762	9.676
	PROXIMAL DIGITAL NERVE SENSORY VELOCITY	mean	39.19	39.96	40.68	40.63	42.26	41.6	42.86	41.46
	(meters/second)	SD	3.602	1.897	2.406	3.695	2.988	2.531	2.386	2.533
		St. error	1.04	0.5477	0.6946	1.067	0.8624	0.7308	0.6887	0.7311
DRG MORPHOMETRY	SOMATIC AREA	mean			643.3	682.4			797.7	645.6 ***	*** p < 0.0001 vs VEH_CDDP end treatment
	(micron²)	SD			338.2	378.2			482.1	404.9	Unpaired t test
		St. error			15.71	15.23			19.46	16.31
	NUCLEAR AREA	mean			94.63	96.05			91.97	86.57 **	** p = 0.0036 vs VEH_CDDP end treatment
	(micron²)	SD			37.46	35.03			37.78	37.38	Unpaired t test
		St. error			1.52	1.41			1.525	1.506
	NUCLEOLAR AREA	mean			7.87	8.31			9.616	7.182 ***	*** p < 0.0001 vs VEH_CDDP end treatment
	(micron²)	SD			5.01	4.92			5.661	4.216	Unpaired t test
		St. error			0.20	0.20			0.2285	0.1699