Figure 7.
Effect of magnesium sulfate on the oxidative stress marker 8-hydroxy-2′-deoxyguanosine (8-OhdG) in the hippocampi of rats exposed to chronic restraint stress (CRS). Administration of magnesium sulfate lowered the increased levels of 8-OHdG [F (3, 20) = 250.7, p < 0.0001] in the hippocampi of rats exposed to CRS. Values are expressed as the mean of 6 rats ± standard deviation (S.D.). Statistical analysis was applied using one-way ANOVA followed by Tukey’s post-hoc test. Significant differences versus control animals are denoted by ** p < 0.01, or **** p < 0.001. Significant differences versus CRS group are denoted by #### p < 0.001. CRS, chronic restraint stress; MgSO4, magnesium sulfate.