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Tonabersat pre-treatment significantly reduced the formation of tortuous and dilated vessels and appeared to reduce the number of beaded vessels (although not reaching statistical significance for the latter). Data are presented as a mean + standard error of the mean (SEM). Statistical analyses were carried out using two-way ANOVA with Sidak’s multiple comparisons test. * p ≤ 0.05, **** p ≤ 0.0001. n = 8–12 eyes per group.
