Table 1.

Summary of dendrimer-modified inorganic nanoparticles in gene and drug delivery.

Nanoparticle	Dendrimer	Outcomes	Ref
SeNP	PAMAM	Improved compaction and protection of plasmid DNA from enzyme digestion, as well as enhanced transgene expression in cervical cancer cells.	[34]
AuNP	PAMAM	Improved mRNA delivery to MCF-7 breast cancer cells by more than 80%.	[36]
		Safe and efficient delivery of plasmid DNA with improved transgene expression.	[35]
		siRNA-based proof-of-principle study showing significant gene silencing in HeLa-tat-Luc cells.	[38]
Fe3O4/SiO2	PAMAM	High drug-loading efficiency (90%) and 95% drug release in vitro.	[97]
AuNP	PEG-PLL Dendrimer	Drug-conjugated dendrimer reduced lung cancer by 95%.	[98]
AuNP	PAMAM	Successfully delivered the METase gene, which inhibited gastric tumor growth.	[99]
Ag–Au	Poly(L-lactide) Dendrimer	Reduced cytotoxicity by 90% and increased drug release by 86%.	[100]
Fe3O4	PAMAM	Induced significant apoptosis in cervical cancer cells.	[101]
	Dendritic Cs-g-mPEG	Successful codelivery of doxorubicin and methotrexate.	[70]
Pd/AuNP	PAMAM	Successful codelivery of gemcitabine and miR-21 inhibitor in pancreatic cancer cells.	[102]