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. 2023 Feb 21;16:641–655. doi: 10.2147/IJGM.S399338

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© 2023 Gao et al.

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The expression of the two selective miRNAs (miR-320e, miR-668-5p) was validated by qRT-PCR. U6 snRNA was used as internal control for normalization. (A) The expression of plasma exosomal miR-320e from CSVD patients was clear downregulated (p<0.0001, Mann–Whitney test). (B) There are no significant differences in plasma exosomal miR-668-5p expression between CSVD and the control group (p=0.062, Mann–Whitney test). Violin plots showed the expression of exosomal miR-320e and miR-668-5p in patients and controls representatively. ****p < 0.0001, CSVD patients vs controls. The y-axis corresponds to miR-320e and miR-668-5p expression levels by log10 change. n = 150 in CSVD group, n = 80 in control group.

Abbreviation: ns, not statistically significant.