Table 1.
Changes in Cx43 of astrocytes, and inflammatory signatures in different neuropsychiatric diseases.
| Disease Types |
Expression | Function | Pro-Inflammatory Cytokines |
Anti-Inflammatory Cytokines | References |
|---|---|---|---|---|---|
| AD | Increase (Around Aβ) |
Inhibition (GJCs) Promotion (HCs) |
↑ | ↓ | [29,30,31] |
| PD | Increase (In rodent striatum) |
— — |
↑ | ↓ | [28] |
| MDD | Decrease | Inhibition (GJCs) Promotion (HCs) |
↑ | ↑ | [6] |
| Epilepsy | Increase (In hippocampus) |
Inhibition (GJCs) Promotion (HCs) |
↑ | ↓ | [28,32,33,34] |
| Glioma | Increase (In the peri-tumor region) |
Inhibition (GJCs) No significant increase (HCs) |
↑ | ↓ | [35,36,37] |
| Ischemic Stroke |
No significant change | Inhibition (GJCs) Promotion (HCs) |
↑ | ↓ | [38,39] |
AD, Alzheimer’s disease; PD, Parkinson’s Disease; MDD, major depressive disorder; Aβ, amyloid β-peptide; GJC, gap junction channel; HC, hemichannel; ↑, Increase; ↓, Decrease.