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. 2023 Feb 6;24(4):3174. doi: 10.3390/ijms24043174

Figure 4.

Figure 4

The effects of three flavonoids on p-ERK1/2 (A,B), p-P38 (C,D), and p-Akt (E,F) protein expression level of Dox-treated H9c2 cells. Cells were pretreated with same concentrations of F-A, F-B, and F-C (10 µM) for 1 h, then exposed to Dox for 24 h. Relative folds of p-Akt, p-ERK1/2, and p-P38. (B,D,F) The relative expression level of p-P38, p-ERK, and p-Akt in Dox group significantly increased compared to the NC group (p < 0.01). There was no significant activation of p-P38, p-ERK, and p-Akt in the F-A, F-B, and F-C group without Dox. However, F-A, F-B, and F-C had no significantly protective effect to reduce protein phosphorylation. Results are mean ± SEM from three independent experiments. ## p < 0.01 vs. control, ** p < 0.01 vs. Dox group. ns, not significant.