Figure 2.

The hypothalamic–pituitary axis ovary endometrium; a summary table of the possible correlations between SARS-CoV-2 infection and transitory alterations of the neuroendocrine and gynecological systems. COVID-19 may lead to a transient suppression of the physiological secretory pulsating activity of the hypothalamic Gonadotropin-Releasing Hormone (GnRH), thus resulting in a temporary hypothalamic hypogonadism. Moreover, SARS-CoV-2 binding to ACE-2 receptors, assumed to be present in endometrial and ovarian tissue as well, could bring to alterations in endocrine pathways and/or coagulation disorders, in both cases resulting in abnormal menstrual bleeding.