Table 2.

Summary of quantitative clinical studies to diagnose idiopathic intracranial hypertension.

Author and Year	Study Design	Study Population	Intervention	Comparator	Results
Dağdelen et al., 2022 [12]	Case-control study	47 adults with IIH	Sonographic ONSD	50 healthy controls	Mean sonographic ONSD wider in cases (6.4 mm vs. 4.9 mm)
					Ideal cut point of 5.7 mm yielding: Sensitivity 100% Specificity 98%
Kishk et al., 2018 [13]	Case-control study	99 females with IIH (90 definite IIH, 9 probable IIH)	Sonographic ONSD	35 age-matched healthy controls	Mean sonographic ONSD wider in cases (6.57 mm vs. 5.50 mm)
					Ideal cut point of 6.05 mm yielding: Sensitivity 73% Specificity 91%
del Saz-Saucedo et al., 2016 [14]	Prospective observational	30 patients with suspected IIH	Sonographic ONSD	Lumbar puncture with CSF opening pressure of ≥25 cmH2O	Mean sonographic ONSD wider in IIH patients (6.8 mm vs. 5.7 mm)
					Idea cut point of 6.3 mm yielding: Sensitivity 95% Specificity 91% +LR 10.4 −LR 0.06
Ebraheim et al., 2018 [15]	Case-control study	24 adults with IIH (20 definite IIH, 4 probable IIH). All cases received acetazolamide treatment.	Sonographic ONSD	30 controls	Mean sonographic ONSD higher in IIH patients (6.7 mm vs. 5.5 mm)
					ONSD was not correlated with CSF opening pressure
					1 week post-LP (10–15 mL withdrawn), mean ONSD not significantly different from baseline (6.6 mm vs. 6.7 mm)
					4 weeks post-LP and after treatment with acetazolamide, mean ONSD decreased from baseline (6.4 mm vs. 6.8 mm)
					Ideal cut point of 6.2 mm yielding: Sensitivity 88% Specificity 100%
Jeub et al., 2020 [16]	Case-control study	19 adults with IIH (15 definite IIH, 4 probable IIH)	Sonographic ONSD	20 healthy controls	Mean sonographic ONSD higher in IIH patients (values not provided)
					24 h after LP (30 mL withdrawn), mean ONSD decreased (mean reduction right eye 0.4 mm, left eye 0.5 mm)
					Ideal cut point of 5.8 mm yielding: Sensitivity 81% Specificity 80%